Prednisone Acetate Tablets
Cusuan Ponisong Pian
Cu Suan Po Ni Song Pian
Cusuanponisong Pian
FUNCTION and INDICATIONS
Mainly used for allergic and autoimmune inflammatory diseases. It is suitable for connective tissue disease, systemic lupus erythematosus, severe bronchial asthma, dermatomyositis, vasculitis and other allergic diseases, acute leukemia, malignant lymphoma and other diseases suitable for adrenocortical hormone drugs.
INGREDIENTS
Prednisone Acetate.
DESCPRIPTION
White tablets.
SPECIFICATION AND PACKAGE
5mg*100 tablets/box.
USAGE AND DOSAGE
Oral, usually 5-10 mg (1-2 tablets) once, 10-60 mg (2-12 tablets) a day. It is up to the doctor to decide if necessary.
1. For systemic lupus erythematosus, nephrotic syndrome, ulcerative colitis, autoimmune hemolytic anemia and other autoimmune diseases, 40-60 mg per day (8-12 tablets per day) can be given, and gradually reduce after the condition is stable. quantity.
2. For allergic diseases such as drug-induced dermatitis, hives, bronchial asthma, prednisone can be given 20-40 mg per day (4-8 tablets per day), and the dose is reduced after symptoms are relieved, and the dose is reduced by 5 mg every 1-2 days (1).
3. To prevent organ transplant rejection, generally 100 mg (20 tablets) per day is taken orally 1-2 days before the operation, and then changed to 60 mg (12 tablets) per day one week after the operation, and the dose is gradually reduced thereafter.
4. For the treatment of acute leukemia and malignant tumors, take 60-80 mg (12-16 tablets per day) orally every day, and reduce the dose after the symptoms are relieved..
REFERENCES
ADVERSE REACTION
Although the effect of this product on sodium retention and potassium excretion is weak, long-term large-scale application can also cause drug-induced hypercortisolism, edema, hypertension, hypokalemia, mental disorders, decreased resistance, abnormal glucose metabolism, bone Psoriasis and adrenal atrophy.
CONTRAINDICATIONS
Hypertension, thrombosis, gastric and duodenal ulcers, psychosis, abnormal electrolyte metabolism, myocardial infarction, visceral surgery, glaucoma, etc. should not be used. Patients with a history of allergy to this product and adrenal corticosteroids are forbidden to use, fungi and viruses Infected persons are disabled.
Warning
Hypertension, diabetes, gastric and duodenal ulcers, cardiac insufficiency, mental illness, osteoporosis, glaucoma, etc. should be used with caution. Appropriate anti-infective treatment must be given to patients with tuberculosis, acute bacterial or viral infections, etc. After long-term use of the drug, the dose should be gradually reduced when the drug is discontinued.
DRUG INTERACTION
medicine interactions
1. Non-steroidal anti-inflammatory analgesics can enhance its ulcerative effect.
2. Can enhance the hepatotoxicity of acetaminophen.
3.Combination with amphotericin B or carbonic anhydrase inhibitor can aggravate hypokalemia. Long-term combined use with carbonic anhydrase inhibitor is prone to hypocalcemia and osteoporosis.
4.Combined with anabolic hormones, it can increase the incidence of edema and make acne worse.
5.Long-term combined use with anticholinergic drugs (such as atropine) can cause increased intraocular pressure.
6.Tricyclic antidepressants can aggravate the mental symptoms caused by them.
7.When used in combination with hypoglycemic drugs such as insulin, the dosage of hypoglycemic drugs should be adjusted appropriately because it can increase the blood sugar of diabetic patients.
8. Thyroid hormone can increase its metabolic clearance rate, so when thyroid hormone or antithyroid drug is used in combination with it, the dosage of the latter should be adjusted appropriately.
9.Combined use with contraceptives or estrogen preparations can enhance its therapeutic effect and adverse reactions.
10.Combination with cardiac glycosides can increase the occurrence of digitalis toxicity and cardiac arrhythmia.
11.Combination with potassium-scavenging diuretics can cause severe hypokalemia and weaken the natriuretic effect of diuretics due to water and sodium retention.
12.Combined with ephedrine, it can enhance its metabolic clearance.
13.Combined use with immunosuppressive agents can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases.
14.It can increase the metabolism and excretion of isoniazid in the liver, and reduce the plasma concentration and curative effect of isoniazid.
15.It can promote the metabolism of mexiletine in the body and reduce the blood concentration.
16.Combined use with salicylate can reduce the concentration of plasma salicylate.
17.Combination with growth hormone can inhibit the growth-promoting effect of the latter.
PHARMACOLOGIC ACTION
Adrenal cortical hormone drugs have anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects. The mechanism of action is:
1.Anti-inflammatory effect: This product reduces and prevents tissue response to inflammation, thereby reducing the manifestations of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at sites of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators.
2.Immunosuppressive effects: including preventing or inhibiting cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, reducing the binding capacity of immunoglobulins to cell surface receptors, And inhibit the synthesis and release of interleukin, thereby reducing the transformation of T lymphocytes to lymphoblastoid cells, and reduce the expansion of the primary immune response. It can reduce the passage of immune complexes through the basement membrane, and can reduce the concentration of complement components and immunoglobulins.
STORAGE
Hermetically sealed,keep in cool and dry places.
PERIOD OF VALIDITY
24 months.
CERTIFICATE NO
Stage Food and Drug Administration Approval number:H34021846.
Manufactured
ANHUI JINTAIYANG PHARMACEUTICAL CO.,LTD
Tips: Please read the directions for use in retail or directed by physician.
Part of the goods frequent replacement of packaging, such as goods and pictures are not exactly the same, please refer to the goods you receive.
General Cautions
Keep away from animals and children.This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.We highly recommend that you consult with a Traditional Chinese Medical practitioner or physician before taking any products or if you have any questions regarding your health.
